Endocrine Abstracts

Introduction: Renin angiotensin system play a crucial role in the development of Diabetes Mellitus and its complications. According many studies, plasma renin level increased at the DM. However, mechanisms of its elevation is not clear yet. The aim of our study was compare plasma renin level in DM1 and DM2 patients and its relationship with glycemic control.Material and Methods: In 44 people with DM1 and 85 with DM2 whose admitted into Hospital of the Re...

Background: There are about 50% of people living with undiagnosed diabetes worldwide. Moreover, by the time of diabetes diagnosis, chronic disabling complications are already present.Aim: To assess level of A1c by the time of type 2 diabetes diagnosis.Material and methods: We analyzed results of type 2 diabetes screening in three regions of the Republic of Uzbekistan among 2521 people aged 35 or older without known carbohydrates me...

Background: Different screening programs recommend starting active search for type 2 diabetes (DM2) at age from 35 to 45. This difference comes from variety in structure of population and weight of age as a risk factor, and also has economical background.The aim of our study: Was to find out the most acceptable cut–off age for DM2 screening in Uzbekistan.Material and Methods: We analyzed results of type 2 diabetes screening i...

Patient Z., 13 years old, transferres to the ICU with diagnosis: Diabetes mellitus newly diagnosed. Diabetic ketoacidotic coma II. Concomitant: Left-sided pneumonia.Objective: Cussmaul’s breath, 36/minute. Pulse 128/min. BP 100/60 mm Hg. Glycemia 30.4 mmol/l, ketones in urine: ++++. CBC, urine, biochemical analysis of blood had not any special features. In the dynamics of the phenomenon of increasing respiratory failure and falling hemodynamics, the...

Introduction: As were previously shown the erythrocytes glucose uptake is impaired in patients with the Diabetes Mellitus, obesity and polycystic ovarian syndrome due to insulin resistance. For further, study whether the erythrocytes glucose uptake will be impaired in rats with experimental metabolic syndrome were observed gradually.Material and methods: The 40 adult white male rats separated into 4 groups. In 10 rats diabetes were induced by injection o...

Background: The COVID-19 pandemic has caused enormous damage to all countries of the world. Patients with diabetes mellitus are a separate risk group for the consequences of COVID-19, both in the acute and in the long-term period.Aim: To study change in the structure of mortality among patients with diabetes in the Republic of Uzbekistan during the COVID-19 pandemic.Materials and Methods: We analyzed the data of the report forms of...

Background: Molecules of adhesion is a group of glycoproteins which expressed in cell surface and play pivotal role in inflammatory and oncological processes, and new studies show increasing of adhesion molecules within 6-12 hours after COVID-19 contamination, peaking in 24 hours. High level of adhesion molecules is a predictor of disease severity and mortality rate.Aim: Of our study was to evaluate the level of VCAM-1 in patients with type 2 diabetes me...

Background: Since the very first outbreak, scientists have been trying to determine the most critical pathogenetic mechanisms for the development of COVID-19 and related complications, analyze individual subpopulations of patients with chronic diseases and develop optimal tactics to combat not only the infection itself but also its acute and chronic complications.Aim: to identify and analyze factors influencing the severity of the COVID-19 course among p...

BackgroundEpidemiological studies revealed up to 5-6 undiagnosed cases of type 2 diabetes mellitus (DM2) per 1 registered patient. The late diagnosis of DM2 presents a medical and socio-economic problem.The aim of the study to identify the most cost-effective, easy-to-use method for regular screening for DM2 in primary care settings in the Republic of Uzbekistan.Materials and methods4 d...